Table 1 Irritancy discrepancies

Perfume chemicals 1 to 10, 11 to 20, 21 to 30, 31 to 39

Perfume chemicals 21 to 30 of 39

chemical Good Scents ChemIDPlus EU/IUCLID other
21. Ethylene brassylate Main page: “irritant”; MSDS: irritating to skin and eyes; irritation “not determined”; human experience “30% solution: no irritation or sensitization.” Skin/eye irritant   RTECS: “primary irritant”
22. gamma methyl ionone Much confusion over identity No MSDSs or references to irritancy for 4 CAS RNs; 50% concentration of 127-51-5 irritant per main page, and MSDS states “irritating to skin”; skin and eye irritation “not determined.” No MSDS or reference to irritancy for other concentrations despite same alternative CAS RN. All 5 CAS RNs: no reference to irritancy   Privi Organics in 2006 (mixture of 3 chemicals): “Full strength may be irritating to skin and eyes”; “causes irritation to eyes and skin”; “may be irritating if inhaled” and “full strength tested on humans produced no irritation. Irritation Data: Eye Rabbit: intense conjunctival irritations. Skin Human: no irritant effects at 2%. Skin Rabbit: irritant effects, erythema = 2, edema = 2”
23. Citronellol Irritant per main page; MSDS states “irritating to skin and eyes”; skin and eye irritation “not determined” Skin/eye irritant    
24. Linalool 78-70-6 irritant per main page; MSDS states irritating to eyes, respiratory system and skin and cites mild human skin irritation and moderate rabbit eye irritation. No MSDS or reference to irritancy for d isomer. Main page for l isomer cites irritancy; MSDS states “irritating to eyes, respiratory system, and skin”, and cites severe rabbit skin irritation and moderate rabbit eye irritation. 78-70-6: skin/eye irritant; irritancy not cited for 126-90-9, the d isomer , or 126-91-0, the l isomer.   RTECS: primary irritant. NIOSH: irritates the eyes and the skin. SIDS: skin irritant...mildly irritant for man
25. Methyl cedrylone Considerable confusion over identity One record has no reference to irritancy; other has main page stating “irritant” and MSDS stating “irritating to skin and eyes”; irritation data “not determined” No reference to irritancy    
26. Verdox MSDS: human experience “4% solution: no irritation or sensitization” but also irritation “not determined”. No reference to irritancy   Privi Organics 2006 MSDS: “Contact with the undiluted material may cause eye and skin irritation.... Applied full strength under occlusion to the skin of rabbit for 24 hours was mildly irritating.” Skin Sensitization (Human) “No irritant effects.” Other previous Privi info: “Causes irritation to eyes and skin... May be irritating if inhaled...Eye Rabbit : Intense conjunctival irritations... Skin Rabbit: Irritant effects, slight to moderate.”
27. Hexyl salicylate No reference to irritancy in 2006. 2008 main page says “irritant” No reference to irritancy   chemBlink: irritating to eyes, skin and respiratory system. Rentokil-Initial: irritant; irritating to skin.
28. Musk indanone No reference to irritancy in 2006. 2008 main page says “irritant” No reference to irritancy    
29. Ambrettolide Confusion over identity Irritant per main page; MSDS states “irritating to eyes”; eye and skin irritation “not determined” and 1% solution: “no irritation or sensitization” in humans No reference to irritancy    
30. Sandela Much confusion over identity No reference to irritancy No reference to irritancy